Process for the production of mycaminosyltylonolide
AssigneeEli Lilly and Company
InventorsRichard H. Baltz, Gene M. Wild, Eugene T. Seno
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Abstract
23-Demycinosyltylosin (DMT) which has the formula: ##STR1## 20-dihydro-DMT, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents. Improved methods of making 5-O-mycaminosyltylonolide (OMT) and 20-dihydro-OMT by mild acid hydrolysis of DMT and 20-dihydro-DMT, respectively, are included.
Claims4
The process for preparing 5-O-mycaminosyltylonolide which comprises treating 23-demycinosyltylosin at a temperature of about 20.degree. C. to about 100.degree. C. with a mild acid solution until 5-O-mycaminosyltylonolide is formed.
The process for of preparing 20-dihydro-5-O-mycaminosyltylonolide which comprises treating 20-dihydro-23-demycinosyltylosin at a temperature of about 20.degree. C. to about 100.degree. C. with a mild acid solution until 20-dihydro-5-O-mycaminosyltylonolide is formed.
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