Substituted phenylalkenoic acids and esters

A pharmaceutical composition useful for treating asthma or for treating or inhibiting blood platelet aggregation comprising a pharmacologically effective amount of the cis isomer of a compound having the formula ##STR12## wherein R is H or C.sub.1 -C.sub.4 alkyl,

• R.sub.1 is H or C.sub.1 -C.sub.4 alkyl,
• R.sup.2 is (i) hydrogen, (ii) C.sub.1 -C.sub.6 alkyl, ##STR13## wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl or aryl;
• or ##STR14## wherein n is 0, 1, 2, or 3;
• m is 0, 1, 2, or 3;
• R.sup.4 and R.sup.5 are individually H or alkyl of 1 to 3 carbon atoms;
• and
• R.sup.6 is selected from the group consisting of
• (A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 nuclear hetero atoms selected from N and S with at least one being N, and with each ring in the said heterocyclic radical containing 5 to 6 members and
• (B) the radical X-R.sup.7 wherein X is --O--, --S--, or --NH-- and R.sup.7 contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 hetero atom in the ring,
• Y is H, halo, C.sub.1 -C.sub.4 alkoxy, carboxy, C.sub.1 -C.sub.6 alkyl or azido, and
• X is H, halo, C.sub.1 -C.sub.4 alkoxy, carboxy, C.sub.1 -C.sub.6 alkyl or azido,
• and pharmaceutically acceptable salts thereof.