Liquid formulations of dihydropyridines
AssigneeBayer Aktiengesellschaft
InventorsDieter Hoff, Klaus-Dieter Ramsch
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Abstract
A rapidly absorbable liquid formulation of a dihydropyridine comprising, by weight, about 0.5 to 10 parts of a dihydropyridine of the formula ##STR1## in which R.sub.1 is C.sub.1 -C.sub.4 -alkyl, optionally substituted by C.sub.2 -C.sub.3 -alkoxy, R.sub.2 is C.sub.1 -C.sub.10 -alkyl, optionally substituted by C.sub.1 -C.sub.3 -alkoxy, trifluoromethyl or N-methyl-N-benzylamino, R.sub.3 is C.sub.1 -C.sub.4 -alkyl, cyano or hydroxymethyl, and X is 2- or 3-nitro, 2,3-dichloro or 2,3.dbd.N--O--N.dbd., 20 to 60 parts of a solubilizing agent and 80 to 40 parts of a diluent.
Claims5
A liquid formulation of a dihydropyridine comprising, by weight, about 1 to 5 parts of a dihydropyridine selected from the group consisting of nisoldipine, nimodipine and 3-methyl 5-trifluoroethyl diester of 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid, 30 to 50 parts of weight of a solubilizing agent comprising glycerol polyethylene glycol oxystearate oxyethylated with about 35, 45 or 60 mols of ethylene oxide and 70 to 50 parts of a diluent consisting essentially of water, ethanol, glycerol, 1,2-propylene glycol, polyethylene glycol 200, polyethylene glycol 400 or polyethylene glycol 600.
Dependencies are inferred from the claim text.