Thrombin inhibiting arylsulfonyl guanidinophenylalanine amides
AssigneeKabiVitrum AB
InventorsCarl G. Claeson, Stig I. Gustavsson
Life of this patent
Estimating the term…
Abstract
New thrombin inhibiting N.sup..alpha. -arylsulfonyl-p-guanidinophenylalanine amides of the formula ##STR1## wherein Ar is a substituted aryl and R.sub.1 and R.sub.2 are an alkyl group having 1-5 carbon atoms or together with the amine nitrogen form an heterocyclic ring, in racemate form as well as in form of optical active antipodes, theirs pharmaceutically acceptable salts, methods for their preparation, pharmaceutical composition and diagnostical preparation containing these compounds, use of the compounds in treatments of thrombosis and methods of treatment of thrombosis as well as methods for determination of thrombin concentration in blood.
Claims14
N.sup..alpha. -arylsulfonyl-p-guanidinophenylalanine amides of the formula ##STR54## wherein Ar is ortho-, meta- or para-tolyl, naphthyl-1, naphthyl-2 or 5-dimethylamino-1-naphthyl;
- R.sub.1 and R.sub.2 are an alkyl group having 1-5 carbon atoms or ##STR55## is a ring system ##STR56## wherein n=2 or 3 and X is a single-bond, CH.sub.2,CH--CH.sub.3, CH--CH.sub.2 H.sub.5, CH--CH.sub.3 H.sub.7, O, NH or N--CH.sub.3, in free base form or in form of pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.