Methods of using compositions having antithrombotic and anti-blood-platelet-aggregating activity

A method for the prevention or treatment of a disease inducing pathological change in blood-platelet-aggregation in a patient subject to or suffering from such a disease, comprising administering to said patient in an amount effective for prevention or treatment of said disease, sulfinpyrazone and a pyridine derivative, for causing antithrombotic and anti-blood-platelet-aggregation activity, the blood platelet aggregation being A.D.P. induced, said pyridine derivative being selected from the group consisting of compounds having the formula:

• ##STR3## in which X represents oxygen or sulfur;
• R is selected from the group consisting of unsubstituted phenyl and benzoyl, phenyl and benzoyl having at least one substituent selected from the group consisting of halogen, straight or branched-chain lower alkyl, straight- or branched-chain lower alkoxy, nitro, amino, sulfonylamino, carboxy, lower alkoxycarbonyl, cyano, phenyl, hydroxy alkyl, methylene-dioxy and ethylene-dioxy, and an alpha-naphthyl group or a thienyl group;
• R.sub.1 represents a hydrogen or halogen atom or a hydroxy group, a straight- or branched-chain lower alkyl group, a straight- or branched-chain lower alkoxy group, or a phenyl group;
• R' represents a lower alkyl group;
• and
• n is an integer from 1 to 15;
• and the symbols R.sub.1 may have different meanings in each radical CHR.sub.1 when n is greater than 1;
• and the pharmaceutically acceptable acid addition salts and quaternary ammonium derivatives of said compounds.