Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors
AssigneeEli Lilly and Company
InventorsRobert D. Titus, Edmund C. Kornfeld
Life of this patent
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Abstract
Trans-(.+-.) 2 and/or 5-permissibly substituted octahydrothiazolo[4,5-g]quinolines and acid addition or quaternary salts thereof and, individual enantiomers thereof, useful as dopamine agonists.
Claims53
A trans-(.+-.)-racemate containing trans-(-) and trans-(+) enantiomers of the formula ##STR14## wherein R is H, C.sub.1-3 straight-chain alkyl or allyl and R.sup.1 is H, halogen, methyl, OH, NH.sub.2, NHC.sub.1-3 alkyl, N(C.sub.1-3 alkyl).sub.2, 1-pyrrolidinyl, NHCOC.sub.1-3 alkyl or NHC.sub.1-2 alkylphenyl and pharmaceutically-acceptable acid addition salts thereof.
A trans-(.+-.) racemate composed of enantiomers of the formulas ##STR15## wherein R.sup.6 is H, CN, benzyl, C.sub.1-3 straight-chain alkyl or allyl and pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.