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US 4,537,891 AGranted
2-(3,5-Substituted-2-pyridylalkylamino)-5-benzyl-4-pyrimidones
AssigneeSmith Kline & French Laboratories Limited
InventorGeorge S. Sach
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Abstract
3,5-Disubstituted-2-pyridylalkylamino-5-optionally substituted benzyl-4-pyrimidones having histamine H.sub.1 -antagonist activity are disclosed.
Claims17
A compound of formula (2):
- ##STR12## or a pharmaceutically acceptable salt thereof;
- where R.sup.1 is halogen, nitro, amino, C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino or C.sub.1-4 alkyl;
- R.sup.2 is halogen, nitro, amino, C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino, C.sub.1-4 alkyl or C.sub.3-4 alkoxy;
- provided that R.sup.1 and R.sup.2 are not both selected from amino, C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino and nitro;
- R.sup.3 is a C.sub.1-3 alkylene group;
- and
- R.sup.4 is phenyl optionally bearing one or two substituents which are the same or different and are halogen, hydroxy, C.sub.1-4 alkyl or C.sub.1-4 alkoxy or a methylenedioxy group.
4 more elements
Dependencies are inferred from the claim text.