Inotropic agents
AssigneeEli Lilly and Company
InventorWayne A. Spitzer
Life of this patent
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Abstract
This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
Claims10
Compounds of the formula ##STR8## and their pharmaceutically acceptable salts, wherein two of A.sub.1, A.sub.2, A.sub.3, and A.sub.4 are N, and the remaining A.sub.1, A.sub.2, A.sub.3, and A.sub.4 are CH, and each of R.sub.1, R.sub.2, and R.sub.3 is independently hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, allyloxy, benzyloxy, (C.sub.1 -C.sub.4 alkyl)thio, (C.sub.1 -C.sub.4 alkyl)sulfinyl, (C.sub.1 -C.sub.4 alkyl)sulfonyl, hydroxy, halo, cyano, amino, mono- or di-(C.sub.1 -C.sub.4 alkyl)amino, trifluoromethyl, or Z-Q-substituted C.sub.1 -C.sub.4 alkoxy, wherein Q is oxygen, sulfur, sulfinyl, sulfonyl, or a bond, and Z is C.sub.1 -C.sub.4 alkyl, phenyl or phenyl substituted with halo C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, nitro, amino, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, or C.sub.1 -C.sub.4 alkylsulfonyl, with the proviso that R.sub.1, R.sub.2, and R.sub.3 may not all be hydrogen at the same time.
Dependencies are inferred from the claim text.