Certain benzazocinone and benzazoninone derivatives
AssigneeCiba-Geigy Corporation
InventorJeffrey W. H. Watthey
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Abstract
Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-benzazocin-2-one and benzazonin-2-one derivatives are disclosed as angiotensin converting enzyme inhibitors and anti-hypertensive agents. Synthesis of, pharmaceutical compositions and methods of treatment utilizing such compounds are included.
Claims11
A compound of the formula ##STR24## wherein S represents the chirality,
- n represents an integer from 1 to 4;
- p is the integer 3 or 4;
- R.sub.8 is hydrogen, amino, benzyloxycarbonylamino, phenyl unsubstituted or monosubstituted by lower alkyl, lower alkoxy, lower alkanoyloxy, halogen, hydroxy, or trifluoromethyl;
- R.sub.6 and R.sub.7 independently represent hydroxy, lower alkoxy of up to 4 carbon atoms, benzyloxy or amino;
- or
- a pharmaceutically acceptable salt thereof.
1-Carboxyme thyl-3-(1-ethoxycarbonyl-3-phenyl-(1S)-propylamino)-3,4,5,6-tetrahydro-(3S) -1-benzazocin-2-1H-one or pharmaceutically acceptable salt thereof.
3-[(5-Amino-1-(S)-carboxypentyl)amino]-1-carboxymethyl-3,4,5,6-t etrahydro-(3S)-1-benzazocin-2-1H-one or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.