4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
AssigneeThe Ohio State University
InventorsDerek Horton, Waldemar Priebe
Life of this patent
Estimating the term…
Abstract
Compounds of the formula (I), acid addition salts thereof, and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R.sup.1 is hydroxy; one of X and X' is hydrogen and the other is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine; one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and --OCOR; one of Z and Z' is hydrogen and the other is hydrogen, hydroxy or --OCOR; and R is a lower alkyl group.
Claims12
Compounds of the formula (I) ##STR4## wherein R.sup.1 is hydroxy;
- one of X and X' is hydrogen and the other is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine;
- one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and --OCOR;
- one of Z and Z' is hydrogen and the other is hydrogen, hydroxy or --OCOR, and R is a lower alkyl group.
A pharmaceutical preparation useful for treating the growth of implanted tumors comprising a carrier and a therapeutically effective amount of a compound of the formula ##STR5## wherein R.sup.1 is hydroxy;
- one of X and X' is hydrogen and the other is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine;
- one of Y and Y' is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and --OCOR;
- one of Z and Z' is hydrogen and the other is hydrogen, hydroxy or --OCOR, and R is a lower alkyl group;
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.