Process for preparing 3-hydroxy-ML-236B derivatives known as M-4 and M-4'
AssigneeSankyo Company, Limited
InventorsAkira Terahara, Minoru Tanaka
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I): ##STR1## (wherein OH represents OH or OH), that is to say M-4 carboxylic acid and M-4' carboxylic acid, as well as pharmaceutically acceptable salts and esters thereof and the corresponding ring-closed lactones may be prepared by contacting an ML-236B compound with a microorganism of the genus Nocardia or a cell-free, enzyme-containing extract thereof and then, if necessary, subjecting the resulting product to one or more of the following reactions: hydrolysis, salification, esterification and lactonisation. The resulting M-4 and M-4' derivatives have the ability to inhibit the biosynthesis of cholesterol and are therefore of value in the therapy and/or prophylaxis of hyperlipaemia and arteriosclerosis.
Claims22
A process for preparing a compound of formula (I):
- ##STR7## wherein OH represents OH or OH, pharmaceutically acceptable salts and esters thereof and the corresponding ring-closed lactones, which process comprises contacting an ML-236B compound selected from the group consisting of ML-236B carboxyic acid, salts and esters thereof and the corresponding ML-236B lactone with a hydroxylation enzyme produced by a microorganism of the genus Nocardia to produce the hydroxylated ML-236B compound of the formula (I).
Dependencies are inferred from the claim text.