Plastatin
AssigneeE. R. Squibb & Sons, Inc.
InventorsJoseph O'Sullivan, Carol A. Aklonis, Pushpa Singh
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Abstract
Plastatin, an inhibitor of the enzyme phospholipase A.sub.2, can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.
Claims4
Plastatin, having the structural formula ##STR2## and pharmaceutically acceptable salts thereof.
A process for preparing plastatin which comprises cultivating Penicillium chermesinum A.T.C.C. No. 20700 in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source under submerged aerobic conditions until substantial phospholipase A.sub.2 inhibitory activity is imparted to the medium.
A biologically pure culture of the microorganism Penicillium chermesinum A.T.C.C. No. 20700, said culture being capable of producing plastatin in a recoverable quantity upon fermentation in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source.
Dependencies are inferred from the claim text.