A52688 Antibiotics and process for their production
AssigneeEli Lilly and Company
InventorsMarie T. Anderson, Karl H. Michel, Thomas H. Sands
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Abstract
New A52688 factors A, C, D, E, F, G, H, J and K which have the common general formula: ##STR1## are antibacterial and antineoplastic agents. Methods of preparing the antibiotics by culturing a strain of Mycoleptodiscus terrestris are provided.
Claims40
A52688 factor A which has the formula ##STR16## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor A.
A52688 factor C which has the formula ##STR17## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor C.
A52688 factor D which has the formula ##STR18## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor D.
A52688 Factor E which has the formula ##STR19## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor E.
A52688 factor F which has the formula ##STR20##
A52688 factor G which has the formula ##STR21## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor G.
A52688 factor H which has the formula ##STR22## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor H.
A52688 factor J which has the formula ##STR23## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor J.
A52688 factor K which has the formula ##STR24## and the C.sub.2 -C.sub.18 -acyl ester derivatives of A52688 factor K.
The method of producing the A52688 antibiotic complex comprising A52688 factors A, C, D, E, F, G, H, J and K which comprises cultivating Mycoleptodiscus terrestris NRRL 15601 or an A52688-producing mutant thereof in a culture medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of A52688 complex is produced.
Dependencies are inferred from the claim text.