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US 4,537,773 AGranted
.alpha.-Aminoboronic acid derivatives
AssigneeE. I. Du Pont de Nemours and Company
InventorAshokkumar B. Shenvi
Life of this patent
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Abstract
.alpha.-Aminoboronic acids and derivatives of formula ##STR1## are potent, reversible inhibitors of aminopeptidases.
Claims22
A compound of the formula ##STR33## wherein R is alkyl or --CH.sub.2 R.sup.1 ;
- R.sup.1 is --XR.sup.2, aryl, or aryl substituted with one or more alkyl groups;
- R.sup.2 is --H, alkyl, or --SiR.sup.3 R.sup.4 R.sup.5 ;
- R.sup.3, R.sup.4 and R.sup.5 are independently alkyl, aryl or aryl substituted with one or more alkoxy groups;
- X is O or S;
- Y is a moiety derived from a dihydroxy compound comprising at least two hydroxy groups separated by at least two connecting atoms in a chain or ring, said chain or ring comprising carbon atoms and, optionally, a heteroatom which can be N, S, or O;
- and
- HW is a mineral acid, sulfonic acid, alkanoic acid or a perfluoroalkanoic acid.
4 more elements
Dependencies are inferred from the claim text.