Stabilization of influenza virus vaccine
AssigneeAmerican Cyanamid Company
InventorCostantino P. Cerini
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Abstract
This invention concerns stabilized influenza virus vaccines and a method of stabilizing influenza viruses and vaccines by the addition of protein hydrolysates and/or amino acids.
Claims21
In a method for stabilizing the immunogenicity of neuraminidase and neuraminidase containing antiviral influenza vaccines neuromidase-stabilizing formulating the vaccine with an effective amount within the range of about 0.0% to about 4.0% w/v of an agent selected from the group consisting of protein hydrolysates, amino acids and combinations thereof.
An improved influenza vaccine effective in eliciting the production of immunizing antibodies in mammals which vaccine contains viral neuraminidase, wherein the improvement consists essentially of a neuromidase stabilizer in said vaccine of a protein hydrolysate or at least one amino acid in sufficient neuromidase-stabilizing quantity within the range of about 0.0% to about 4.0% w/v to stabilize the enzymatic activity of the neuraminidase.
Dependencies are inferred from the claim text.