Dimethylphosphoramidates
AssigneeDevelopment Finance Corporation of New Zealand
InventorsGordon W. Rewcastle, Graham J. Atwell, Bruce C. Baguley, William A. Denny
Life of this patent
Estimating the term…
Abstract
The novel class of compounds of the present invention represented by the general formula (I): ##STR1## in which R.sub.1 represents H or OCH.sub.3, R.sub.2 represents H, OCH.sub.3, CH.sub.3, halogen, NO.sub.2, NH.sub.2, NHCOCH.sub.3 or NHCOOCH.sub.3, and R.sub.3 and R.sub.4 individually represent H, CH.sub.3, OCH.sub.3 or CONHCH.sub.3, and the acid addition salts thereof, have unexpectedly high potency and activity in in vivo antitumor tests. The compounds are also bacteriostatic, and show toxicity towards mouse, hamster and human tumor cell lines in culture.
Claims1
A compound of the general formula (III):
- ##STR7## where R.sub.1 is H or OCH.sub.3.
Dependencies are inferred from the claim text.