4-Methylsulfonyl-azetidinone derivatives
AssigneeAjinomoto Co., Inc.
InventorsToshihisa Kato, Hisao Iwagami, Naohiko Yasuda
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Abstract
The present invention relates to novel azetidinone derivatives of the general formula: ##STR1## where n is 0 or 2, X is hydrogen, halogen, amino, alkylamino, benzylamino or acylamino, and Y is ##STR2## R is lower alkyl, 2,2,2-trichloroethyl, or aralkyl; and M is hydrogen or alkali metal having .beta.-lactamase inhibiting activity. The derivatives of the present invention can be administered together with antibiotics having a .beta.-lactam ring as antibacterial agents against .beta.-lactamase producing bacteria. A method for synthesizing said azetidinone derivatives is also disclosed.
Claims6
Azetidinone derivatives represented by the formula:
- ##STR26## wherein X is hydrogen, halogen, amino, methylamino, ethylamino, benzylamino, dimethylamino or acylamino selected from the group consisting of acetamide, arylacetamide, 2-amino-2-arylacetamide, 2-acylamino-2-arylacetamide, or D(-)1-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamide)-.alpha.-(4-hydro xyphenyl)acetamide);
- and
- Y is ##STR27## wherein R is lower alkyl, benzyl, or 2,2,2-trichloroethyl, and M is hydrogen or alkali metal.
Dependencies are inferred from the claim text.