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US 4,537,718 AGranted
Impermeant spectroscopic probes
AssigneeColumbia University in the City of New York
InventorsDavid Schachter, Richard E. Abbott, Uri Cogan
Life of this patent
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Abstract
Lipid-soluble impermeant spectroscopic probes for the study of intact biological membranes are disclosed.
Claims6
An impermeant spectroscopic probe, comprising:
- glutathione joined by a linkage group to a spectroscopic reporter group, wherein
- (1) said linkage group is selected from the group consisting of ##STR33## wherein n is 2, 4, 6, 8 or 10;
- ##STR34## (2) said spectroscopic reporter group is selected from the group consisting of pyrenes, nitrobenz-oxa-diazoles, anthracenes, coumarins, acridines, anthranilates, bimanes, stilbenes, parinaric acids, and N-oxyl-4,4-dimethyloxayolidine derivatives of ketostearic acids or 2,2,5,5-tetramethyl-3-pyrrolin-1-oxyl-3-carboxylic acid.
Dependencies are inferred from the claim text.