Des-serine.sup.2 or des-glycine.sup.2 -leucine.sup.22 calcitonin
AssigneeArmour Pharmaceutical Company
InventorsRonald C. Orlowski, Jay K. Seyler
Life of this patent
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Abstract
New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
Claims3
Des-X.sup.2 -Leu.sup.22 -Calcitonin wherein X is serine or glycine, said calcitonin being a salmon, eel or human calcitonin deletion analog.
A peptide having the structure:
- ##STR27##
A peptide having the structure:
- ##STR28## where R.sub.1 is S-n-alkyl in which the alkyl group is methyl, ethyl, n-propyl or n-butyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H.
Dependencies are inferred from the claim text.