Process for the reduction of reducible groups and its use

Process for the reduction of reducible groups characterized in that an effective amount of a platinum-metal-phthalocyanine of the following formula is used as the catalyst:

• ##STR13## where M is a metal of the platinum metal series, X.sup.1-4 is halogen, cyano or optionally other substituents with --I-- effect, alkyl or aryl, while X.sup.2-3 can also be components of an annellated ring system or poly-Pc-structure, and X.sup.1-4 can independently substitute one or more of the benzoid rings, for a selective reduction at a temperature of 0.degree. C. to 200.degree. C. with an effective amount of a suitable reduction agent on [MPc].sup.- with M having a formal charge z.ltoreq.1 to reduce the functional groups C.dbd.C, C.dbd.N, C.tbd.N, C.dbd.O, NO.sub.2, alkyl halogenides and carbonic acid halogenides is obtained.

Process for the removal of reducible protecting groups from a protected amino acid(s) or oligo- and polypeptide(s) characterized in that an effective amount of a platinum-metal-phthalocyanine of the following formula is used as the catalyst:

• ##STR14## where M is a metal of the platinum metal series, X.sup.1-4 is halogen, cyano or optionally other substituents with --I-- effect, alkyl or aryl, while X.sup.2-3 can also be components of an annellated ring system or poly-Pc-structure, and X.sup.1-4 can independently substitute one or more of the benzoid rings, for a selective reduction at a temperature of 0.degree. C. to 200.degree. C. with an effective amount of hydrogen on [MPc], with M having a formal charge z.gtoreq.2 to reduce the functional groups C.dbd.C, C.dbd.N, aromatic NO.sub.2, aromatic CH.dbd.O, benzyl esters and aromatic halogen compounds, the latter being only reduced in a basic medium.

Process for the removal of reducible protecting groups from a protected amino acid(s) or oligo- and polypeptide(s) characterized in that an effective amount of a platinum-metal phthalocyanine of the following formula is used as the catalyst:

• ##STR15## where M is a metal of the platinum metal series, X.sup.1-4 is halogen, cyano or optionally other substituents with --I-- effect, alkyl or aryl, while X.sup.2-3 can also be components of an annellated ring system or poly-Pc-structure, and X.sup.1-4 can independently substitute one or more of the benzoid rings, for a selective reduction at a temperature of 0.degree. C. to 200.degree. C. with an effective amount of a suitable reduction agent on [Mpc].sup.- with M having a formal charge z.ltoreq.1 to reduce the functional groups C.dbd.C, C.dbd.N, C.tbd.N, C.dbd.O, NO.sub.2, alkyl halogenides, especially by the reductive fragmentation of .beta.-halogenalkyl groups, and carbonic acid halogenides is obtained.