Process for the preparation of alpha-aryl-propionic acids and alkaline salts thereof
AssigneeMontedison S.p.A.
InventorsAndrea Gardano, Franco Francalcanci, Marco Foa
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Abstract
Alpha-arylpropionic acids and alkaline salts thereof are prepared by catalytic reaction with carbon monoxide of the corresponding secondary halids in an anhydrous low alcohol solvent in the presence of a salt of cobalt hydrocarbonyl and in further presence of alkaline hydroxides under substantially ambient temperature and pressure conditions. The products obtained find useful applications in the field of pharmaceutics (analgesics, antipyretics, etc.) and as intermediates for chemical syntheses of fine chemicals, phytodrugs, etc.
Claims16
A process for the preparation of alkaline salts of alpha-arylpropionic acids having formula (I):
- ##STR10## wherein Ar represents an aromatic or heteroaromatic group containing one or more rings, however linked to each other, having in total up to 20 carbon atoms, by reaction with carbon monoxide, of the corresponding secondary haildes of formula (II):
- ##STR11## wherein Ar has the same meaning as in formula (I) and where X is a halogen selected from Cl and Br, characterized in that the reaction is conducted in an anhydrous alcoholic solvent medium consisting of alkanols having up to 4 carbon atoms, in the presence of alkaline hydroxides, and in presence, as catalyst, of a salt of cobalt hydrocarbonyl, at a temperature comprised between 0.degree. C. and 50.degree. C. and at substantially atmospheric pressure.
Dependencies are inferred from the claim text.