2-Substituted prostaglandins
AssigneeG. D. Searle & Co.
InventorsPaul W. Collins, Alan F. Gasiecki, Richard M. Weier
Life of this patent
Estimating the term…
Abstract
The present invention encompasses 16-alkyl, 16-hydroxy-2-substituted prostaglandins which exhibit cytoprotective and antisecretory activity with greatly reduced diarrhea side effects.
Claims6
A compound which is methyl 7-[3.alpha.-hydroxy-2.beta.-4(RS)-4-hydroxy-4-methyl-1-trans-octenyl)-5-ox ocyclopentane]-1.alpha.-2-allyl heptanoate.
A compound which is methyl 7-[3.alpha.-hydroxy-2.beta.-4(RS)-4-hydroxy-4-methyl-1-trans-octenyl)-5-ox ocyclopentane]-1.alpha.-2-benzyl-heptanoate.
A compound which is methyl 7-[3.alpha.-hydroxy-2.beta.-4(RS)-4-hydroxy-4-methyl-1-trans-octenyl)-5-ox ocyclopentane]-1.alpha.-2-cyclopentyl heptanoate.
A compound which is methyl 7-[3.alpha.-hydroxy-2.beta.-4(RS)-4-hydroxy-4-methyl-1-trans-octenyl)-5-ox ocyclopentane]-1.alpha.-2-iodo-heptanoate.
A compound which is ethyl 7-[3.alpha.-hydroxy-2.beta.-4(RS)-4-hydroxy-4-methyl-1-trans-octenyl)-5-ox ocyclopentane]-1.alpha.-2-fluoro-heptanoate.
A compound which is methyl 7-(3.alpha.-hydroxy-2.beta.-4(RS)-4-hydroxy-4-methyl-1-trans-octenyl-5-oxo cyclopentane]-1.alpha.-2-phenyl-heptanoate.
Dependencies are inferred from the claim text.