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US 4,536,579 AGranted
Pyrimidines substituted by nitrogen-containing heterocyclic rings as intermediates
AssigneeRiker Laboratories, Inc.
InventorJames J. Wade
Life of this patent
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Abstract
1,2,4-Triazolo[4,3-c]pyrimidines substituted at the 5 or 7 position through a nitrogen atom which is part of a heterocyclic ring have been found to have potent bronchodilator activity and to be useful synthetic intermediates in the preparation of 1,2,4-triazolo[1,5-c]pyrimidines. Methods for inducing bronchodilation, pharmaceutical compositions, and synthetic processes and intermediates are also described.
Claims2
A compound of the formula ##STR95## wherein R.sub.5 is hydrogen, lower alkyl, phenyl or lower alkylthio;
- R.sub.8 is hydrogen, phenyl or lower alkyl;
- and X is oxygen, sulfur, sulfinyl, sulfonyl, methylene, imido or N-lower alkylimido.
A compound of the formula ##STR96## wherein R.sub.5 is hydrogen, lower alkyl, phenyl or lower alkylthio;
- R.sub.8 is hydrogen, phenyl or lower alkyl;
- and X is oxygen, sulfur, sulfinyl, sulfonyl, methylene, imido or N-lower alkylimido.
Dependencies are inferred from the claim text.