Amido-phenyl-.alpha.-D-glucopyranoside derivatives
AssigneeUniversity of Utah
InventorsWan S. Kim, Seo Y. Jeong, James C. McRea
Life of this patent
Estimating the term…
Abstract
Synthesized succinyl and glutaryl glucosamines, p-(succinylamido)-phenyl-.alpha.-D-gluco- and mannopyranosides, p-(glutarylamido)-phenyl-.alpha.-D-gluco- and mannopyranosides and p-(isothiocyanotophenyl)-.alpha.-D-gluco- and mannopyranosides are reacted with insulin to form corresponding glycosylated insulins containing from 1 to 3 glycosyl groups per insulin molecule. The novel glycosylated insulins resist aggregation and show significant activity in depressing blood sugar levels.
Claims7
A compound of the formula ##STR20## wherein X and Z are different and are selected from the group consisting of --H and --OH and n is an integer of 2 to 6.
Dependencies are inferred from the claim text.