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US 4,536,571 AGranted
Selenium-containing platinum compound
OwnerRichard F. Stockel, Philip E. Dumasinventors
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Abstract
The toxic effects of platinum compounds used in chemotherapy can be negated by the use of a selenium-containing compound. A new selenium-containing platinum compound has been found to be useful as a so-called platinum compound type anti-cancer medicine which can self-detoxify platinum toxicity.
Claims23
A selenium-containing platinum compound having the general formula(1) ##STR80## wherein R and R' each independently stand for
- a selenoalkylmonoamine,
- a selenoamino acid having one amino group,
- an unsubstituted or substituted selenoglucose radical,
- an unsubstituted or substituted selenogalactose radical, or
- an unsubstituted or substituted selenomannose radical;
- or
- R and R' together stand for
- a selenoalkyldiamine,
- a selenoaralkyldiamine,
- a selenoamino acid having two amino groups,
- a selenonucleic acid base radical,
- a selenoribosylnucleic acid base radical, or
- an unsubstituted or substituted selenosemicarbazide;
- and
- X and X' each independently stand for Cl, No.sub.2, or NO.sub.3, or
- X and X' together stand for >SO.sub.3, >SO.sub.4 or ##STR81##
13 more elements
Dependencies are inferred from the claim text.