Alkene derivatives
AssigneeImperial Chemical Industries PLC
InventorsMichael J. K. Harper, Dora N. Richardson, Arthur L. Walpole, deceased
Life of this patent
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Abstract
Triphenylalkene derivatives, in particular 1-(p-.beta.-dimethylaminoethyoxyphenyl)-1,2-diphenylbut-1-ene, which possess utility as anti-oestrogens.
Claims6
The geometric isomer of 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1ene, and the pharmaceutically acceptable, acid addition salts thereof, which is identified by its citrate having a melting point of 140.degree.-142.degree. C.
1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1,2-diphenylbut-1-ene and the pharmaceutically acceptable, acid addition salts thereof.
1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate of melting point 140.degree.-142.degree. C.
In a process for the treatment of hormone dependent tumors, the improvement which comprises treating said tumors with an effective amount of a member of the group consisting of the geometric isomer of 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene, and the pharmaceutically acceptable, acid addition salts thereof, which isomer is identified by its citrate having a melting point of 140.degree.-142.degree. C.
In a process for the treatment of hormone dependent tumors, the improvement which comprises treating said tumors with an effective amount of a member selected from the group consisting of 1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1,2-diphenylbut-1-ene and the pharmaceutically acceptable, acid addition salts thereof.
In a process for the treatment of hormone dependent tumors, the improvement which comprises treating said tumors with an effective amount of 1-(p-.beta.-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate of melting point 140.degree.-142.degree. C.
Dependencies are inferred from the claim text.