Substituted phenylalkenoic acids and esters

A pharmaceutical composition useful for treating asthma, or treating or inhibiting blood platelet aggregation in humans containing an effective amount of a compound having the formula ##STR17## wherein R is H or C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or hydroxy,

• R.sup.1 is H or C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or hydroxy,
• R.sup.2 is
• (i) hydrogen,
• (ii) C.sub.1 -C.sub.6 alkyl,
• (iii) ##STR18## wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl or aryl or
• (iv) ##STR19## wherein n is 0, 1, 2, or 3;
• m is 0, 1, 2, or 3;
• R.sup.4 and R.sup.5 are individually H or alkyl of 1 to 3 carbon atoms and;
• R.sup.6 is selected from the group consisting of
• (A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 nuclear hetero atoms selected from N and S with at least one being N, and with each ring in the said heterocyclic radical containing 5 to 6 members and
• (B) the radical X.sup.1 --R.sup.7 wherein X.sup.1 is --O--, --S--, or --NH-- and R.sup.7 contains up to 21 carbon atoms and is (1) hydrocarbon radical or (2) an acyl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 hetero atom in the ring,
• Y is H, halo, hydroxy, C.sub.1 -C.sub.4 alkoxy or azide,
• X is H, halo, hydroxy, C.sub.1 -C.sub.4 alkoxy or azide, and
• Z is 3, 5, or 7,
• and pharmaceutically acceptable salts thereof.