7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease

A compound having the structural formula ##STR23## and including all stereoisomers thereof;

• wherein
• A is a single bond or --CH.sub.2 --;
• m is 0 when A is --CH.sub.2 -- and m is 1 when A is a single bond;
• B is --CH.dbd.CH-- or (CH.sub.2).sub.2 ;
• R is H, lower alkyl or alkali metal;
• and R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, wherein the term lower alkyl or alkyl by itself or as part of another group contains 1 to 12 carbons and is unsubstituted or substituted with halo, trifluoromethyl, alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl or alkylcycloalkyl;
• the term aryl by itself or as part of another group contains 6 to 10 carbons and is unsubstituted or substituted with 1 or 2 lower alkyl groups, 1 or 2 halogens and/or 1 or 2 lower alkoxy groups;
• the term cycloalkyl by itself or as part of another group contains 3 to 12 carbons and is unsubstituted or substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups and/or 1 or 2 lower alkoxy groups;
• and
• the term lower alkenyl by itself or as part of another group contains 2 to 12 carbons.