Naphthoxyalkylamines and related compounds as antiinflammatory agents
AssigneeSyntex (U.S.A.) Inc.
InventorsPeter H. Nelson, Howard J. Ringold, Stefan H. Unger, Thomas R. Thieme
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AssigneeSyntex (U.S.A.) Inc.
InventorsPeter H. Nelson, Howard J. Ringold, Stefan H. Unger, Thomas R. Thieme
Estimating the term…
Compounds of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein; Y is halo, alkoxy, alkyl, or dialkylamino; a is 0, 1 or 2; b is an integer from 2-12 with the proviso that if b is 2 or 3 a cannot be 0; and X is selected from the group consisting of: --OH, OR.sup.1, --NH.sub.2, --NHR.sup.1, NR.sub.2.sup.1, ##STR2## and --NHCONHR.sup.2 in which each R.sup.1 is independently alkyl or cycloalkyl or in --NR.sub.2.sup.1, both R.sup.1 together are alkylene or form a piperazine ring optionally substituted at the ring N by alkyl or --CH.sub.2 CH.sub.2 OH; and R.sup.2 is alkyl, cycloalkyl, or optionally substituted phenyl; have antiinflammatory properties and are useful in the treatment of conditions characterized by inflammation and swelling.
A method for inhibiting, preventing, or reducing inflammation, which method comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound of the formula:
A method for inhibiting, preventing, or reducing inflammation, which method comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound selected from the group consisting of;
Dependencies are inferred from the claim text.