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US 4,536,500 AGranted
Aromatic derivatives comprising an aminoalkoxy chain and pharmaceutical compositions thereof
AssigneeDelalande S.A.
InventorsGuy R. Bourgery, Alain P. Lacour, Bernard M. Pourrias, Raphael Santamaria
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Abstract
New aromatic derivatives having an activity antagonistic to calcium and corresponding to formula: ##STR1## in which: A represents a chain having any one of the following structures: ##STR2## Ar represents a group of structure: ##STR3## n takes the value 1 or 2 when R is different from H; m takes the value 2 or 3.
Claims6
New aminoalkoxy aromatics, corresponding to the general formula:
- ##STR259## in which:
- R represents hydroxyl;
- n takes the value 1 or 2 when R is different from H;
- m takes the value 2 or 3;
- A represents a chain having any one of the following structures:
- ##STR260## the aromatic group Ar being linked to position 1 of this chain, R.sub.1 and R.sub.2 form in conjunction with the nitrogen atom to which they are linked a radical chosen from the following:
- pyrrolidino, piperidino, hexamathyleneimino, morpholino;
- and
- Ar represents:
- either a benzene group of structure:
- ##STR261## in which R.sub.3 represents a halogen atom or a nitro or methyl group, R.sub.4 =alkoxy with 1 to 4 carbon atoms, p=0, 1 or 2;
- q=1, 2, 3, 4;
- p+q.ltoreq.4 or a naphthalene or benzodioxannic group respectively of structure:
- ##STR262## where R.sub.4 has the same meanings as previously, as well as their mineral or organic acid addition salts.
11 more elements
Dependencies are inferred from the claim text.