6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
AssigneePfizer Inc.
InventorWayne E. Barth
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Abstract
6-alpha- and 6-beta-(Aminomethyl)penicillanic acid, 1,1-dioxide esters which are hydrolyzable under physiological conditions, particularly those wherein the ester radical is 1H-isobenzofuran-3-on-1-yl or (5-methyl-1,3-dioxol-2-on-4-yl)methyl, and an improved process and intermediates used in their synthesis.
Claims17
A beta-lactam ester of the formula ##STR11## wherein Y is ##STR12## or a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula ##STR15## wherein Y' is (C.sub.1 -C.sub.3)alkyl and R.sup.1 is hydrogen, or a conventional ester forming radical which is hydrolyzable under physiological conditions, or cationic salts therof when R.sup.1 is hydrogen.
Dependencies are inferred from the claim text.