Method for controlling hemophilia in mammals
AssigneeQueen's University at Kingston
InventorsAlan R. Giles, Kenneth G. Mann
Life of this patent
Estimating the term…
Abstract
A method for controlling HemophiliaA (Antihemophilic Factor (F. VIII:C) deficiency) in mammals is described. Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic).
Claims6
A method for controlling hemophilia in mammals comprising administering intravenously to a hemophilic said mammal a synergistic mixture of phospholipid vesicles and mammalian blood factor Xa in relative proportion and in an amount just sufficient to arrest bleeding.
Dependencies are inferred from the claim text.