Process for preparing urokinase complex
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsWasei Miyazaki, Tsuneo Sato, Yasuo Nakayama, Tadao Sato
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Abstract
This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula ##STR1## wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and l, m and n are each 0 or 1 provided that l, m and n are not 0 at the same time. The complex is useful as a thrombolytic agent.
Claims17
A plasmin heavy chain urokinase complex prepared by a process comprising reacting a plasmin heavy chain with urokinase in the presence of a protein coupling reagent represented by the formula ##STR32## wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and l, and m and n are each 0 or 1 provided that l, m and n are not 0 at the same time.
Dependencies are inferred from the claim text.