2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
AssigneeAmerican Home Products Corporation
InventorsG. E. Morris Husbands, John P. Yardley, Eric A. Muth
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Abstract
This invention provides a group of hydroxycycloalkanephenethyl amine antidepressant derivatives of the following structural formula: ##STR1## in which A is a moiety of the formula ##STR2## where the dotted line represents optional unsaturation; R.sub.1 is hydrogen or alkyl; R.sub.2 is alkyl; R.sub.4 is hydrogen, alkyl, formyl or alkanoyl; R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl or, taken together, methylenedioxy; R.sub.7 is hydrogen or alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claims32
A compound of the formula:
- ##STR17## wherein the dotted line represents optional olefinic unsaturation, and
- R.sub.1 is hydrogen or alkyl of 1 to 6 carbon atoms;
- R.sub.2 is alkyl of 1 to 6 carbon atoms;
- R.sub.4 is hydrogen, alkyl of 1 to 6 carbon atoms, formyl, or alkanoyl of 2 to 7 carbon atoms;
- R.sub.5 and R.sub.6 are independently hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, nitro, alkylmercapto of 1 to 6 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino in which each alkyl group is of 1 to 6 carbon atoms, alkanamido of 2 to 7 carbon atoms, halo, or trifluoromethyl;
- R.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms;
- and
- n is one of the integers 0, 1, 2, 3 or 4;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.