Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation
AssigneeBurroughs Wellcome Co.
InventorGeoffrey Kneen
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Abstract
This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in the palliation of pulmonary dyefunction, protection from the effects of hypoxia and the radio-sensitization of tumours. The invention is also directed to methods for the preparation of the ether compounds, to pharmaceutical formulations containing them, the preparation of such formulations and the use of the compounds in human medicine. Also provided by the invention are intermediates of value in the preparation of the ether compounds, by the methods described, and the preparation of the intermediates.
Claims21
4-(2-Formyl-3-hydroxyphenoxymethyl)benzoic acid and salts thereof.
4-(2-Formyl-3-hydroxyphenoxymethyl)benzoic acid.
A pharmacologically acceptable salt of 4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid.
A pharmaceutical formulation comprising 4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid, or a pharmacologically acceptable salt thereof, together with an acceptable carrier therefor.
A method for the palliation of pulmonary dysfunction in a human being having such a condition which comprises administering to said human being a non-toxic, effective palliative amount of the acid according to claim 12 or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.