Process for the preparation of [2,2]-paracyclophane
AssigneeMerck Patent GmbH
InventorHartmut Hartner
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Abstract
A process for the preparation of [2,2]-paracyclophane comprises contacting aqueous p-methylbenzyltrimethylammonium hydroxide with sodium hydroxide or potassium hydroxide, in the presence of dimethyl sulfoxide, and preferably in the further presence of an inert water-immiscible organic solvent.
Claims9
A process for preparing [2,2]-paracyclophane, comprising the step of contacting aqueous p-methylbenzyltrimethylammonium hydroxide with sodium hydroxide or potassium hydroxide, in the presence of dimethyl sulfoxide.
In a process for preparing [2,2]-paracyclophane by Hofmann elimination, wherein p-methylbenzyltrimethylammonium hydroxide is heated and resultant [2,2]-paracyclophane is recovered, the improvement wherein the reaction is effected by heating aqueous p-methylbenzyltrimethylammonium hydroxide, in contact with an inert water-immiscible organic solvent, and in the presence of dimethyl sulfoxide.
Dependencies are inferred from the claim text.