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OwnerWilliam G. Malette, Herbert J. Quigleyinventors
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The method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration is described wherein a chitosan solution, or water-soluble chitosan in various solid forms is placed in contact with the tissue wound. The chitosan forms a coagulum which prevents bleeding and negates the formation of a blood clot thereby preventing the formation of fibrin strands. The prevention of the formation of fibrin strands prevents the proliferation of fibroblasts and the synthesis of collagen thereby allowing the promotion of normal tissue regeneration. The process described hereinabove results in wound healing with minimal scar formation. The use of chitosan in grafts is contemplated as well as the use of polyglucosamine in wound healing.
The method of inhibiting fibroplasia and promoting tissue regeneration in vascular grafts which comprises placing, an effective amount of chitosan in contact with the graft, said chitosan being between 42 to 100 percent deacetylated;
The method of inhibiting fibroplasia and promoting tissue regeneration in a wound which comprises placing in contact with said wound an effective amount of chitosan, said chitosan being between 42 to 100 percent deacetylated;
The method of achieving hemostasis, inhibiting fibroplasia and for promoting tissue regeneration in a wound which comprises placing an effective amount of polyglucosamine in contact with the wound.
Dependencies are inferred from the claim text.