6- And 6,6-disubstituted-3-substituted amino-1-azabicyclo-[3.2.0]hept-2-en-7-one-2-carboxylic acid

A compound having the structural formula:

• ##STR97## and the pharmaceutically acceptable salts, thereof, wherein:
• R' and R" are independently selected from the group consisting of hydrogen, substituted with 1-3 substituents and unsubstituted:
• alkyl and cycloalkyl having 1-10 carbon atoms, phenylalkyl and heterocyclylalkyl wherein the alkyl moiety has 1-6 carbon atoms and the heterocyclyl is selected from ##STR98## wherein the ring or chain substituent or substituents on R', R", or the cyclic radical formed by their joinder are selected from amino, mono- or di-alkylamino (each alkyl having 1-6 carbon atoms), hydroxyl, carboxyl, alkoxyl having 1-6 carbon atoms, chloro, bromo, fluoro, nitro, sulfamoyl, phenyl, benzyl, and alkoxycarbonyl having 1-3 carbon atoms in the alkoxyl moiety;
• and R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen, substituted and unsubstituted:
• alkyl, alkenyl, and alkynyl, having from 1-10 carbon atoms;
• cycloalkyl, cycloalkylalkyl, and alkylcycloalkyl, having 3-6 carbon atoms in the cycloalkyl ring and 1-6 carbon atoms in the alkyl moieties;
• phenyl;
• aralkyl, aralkenyl, and aralkynyl wherein the aryl moiety is phenyl and the alkyl chain has 1-6 carbon atoms;
• wherein the substituent or substituents relative to the above-named radicals are selected from the group consisting of:
• amino, mono- or di-alkylamino, hydroxyl, alkoxyl, mercapto, alkylthio, phenylthio, sulfamoyl, amidino, guanidino, nitro, chloro, bromo, fluoro, cyano and carboxy;
• and wherein the alkyl moieties of the above-recited substituents have 1-6 carbon atoms;
• when R.sup.1 /R.sup.2 is hydrogen, R.sup.2 /R.sup.1 is not 1-hydroxyethyl.