Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
AssigneesStolle Research & Development Corporation, Southern Research Institute
InventorsThomas R. Tice, Danny H. Lewis, Donald R. Cowsar, Lee R. Beck
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Abstract
An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.
Claims12
An anti-inflammatory agent containing microparticle composition prepared by a process, comprising:
- (a) dissolving or dispersing an anti-inflammatory agent selected from the group consisting of a prednisolone, a triamicinolone, a dexamethasone and a .beta.-methasone in a solvent selected from the group consisting of acetone, a halogenated hydrocarbon, an aromatic hydrocarbon. a halogenated aromatic hydracarbon, a cyclic ether, an alcohol and water and dissolving a biocompatible and biodegradable wall forming material in said solvent;
- (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium of water, toluene, xylene, a synthetic oil or a natural oil;
- (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension;
- and
- (d) extracting the remainder of the solvent from said microparticles.
Dependencies are inferred from the claim text.