Conjugates of anticoagulant and protein

A process for the improvement of compatibility between blood and a substrate, the process including coating the substrate with an anticoagulant material, wherein the process comprises chemically attaching a protein-anticoagulant conjugate having been prepared according to a process that includes selecting a water soluble human protein as said protein, coupling said anticoagulant to said protein within an aqueous medium and in the presence of a coupling agent and providing an anticoagulant-protein conjugate by using a coupling agent that is an amide bond forming agent to form an amide linkage between said anticoagulant and said protein, and the protein of said protein-anticoagulant conjugate is non-crosslinked and soluble when chemically attached to said substrate.

A process for the improvement of compatibility between blood and a substrate, the process including coating the substrate with anticoagulant material, wherein the process comprises coating the substrate with a protein component, said protein component being a non-crosslinked protein, wherein said protein component is a water soluble human protein that is coupled with anticoagulant by a procedure utilizing an amide bond forming agent as a coupling agent, said procedure being such that the coupled protein and anticoagulant is substantially non-crosslinked when coated onto the substrate.

A process for the improvement of compatibility between blood and a substrate, the process including coating the substrate with anticoagulant material, wherein the process comprises covalently linking a protein component to a substrate, said protein component being a non-crosslinked protein, wherein said protein component is a water soluble human protein that is coupled with anticoagulant by a procedure utilizing an amide bond forming agent as a coupling reagent, said procedure being such that the coupled protein and anticoagulant is substantially non-crosslinked when coated onto the substrate.