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US 4,521,424 AGranted
Quinate salts of the antimalarial compound mefloquine
AssigneeSmithKline Beckman Corporation
InventorJean F. Rossignol
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Abstract
The compound of formula (I) ##STR1## possesses markedly increased solubility under aqueous conditions and improved pharmacokinetic profile against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.
Claims6
A compound represented by the following structural formula (I):
- ##STR4## which is .alpha.-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol quinate
Dependencies are inferred from the claim text.