Anti-coagulants of the 4-hydroxycoumarin type and rodenticidal compositions (baits) comprising such anti-coagulants
AssigneeShell Oil Company
InventorsIan D. Entwistle, Peter Boehm
Life of this patent
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AssigneeShell Oil Company
InventorsIan D. Entwistle, Peter Boehm
Estimating the term…
Compounds having blood-anticoagulant properties of the general molecular formula: ##STR1## in which Z represents a halogen atom, preferably a chlorine atom, and n is 0, 1 or 2 and R.sup.4 represents either (1) a grouping which comprises a phenylene radical attached directly or indirectly to the tetralin ring and having in the para position (with respect to such attachment) an electron-withdrawing atom or group whose rotational volume substantially does not exceed that of a phenyl group and which forms together with said phenylene radical a polarizable structure, or (2) a grouping selected from: ##STR2## or (3) a grouping which comprises a phenylene radical attached directly to the tetralin ring and having in the para position (with respect to such attachment) a substituted furanyl or thiophenyl radical attached thereto directly or through oxygen and/or methylene, said furanyl or thiophenyl radical having such an electron-withdrawing atom or group as a substituent in a position forming with the furanyl or thiophenyl radical a polarizable structure, compounds of the type (1) in which R.sup.4 contains two phenylene radicals linked essentially linearly by an aliphatic chain comprising a methylene radical or radicals and optionally at least one oxygen or sulphur atom being preferred. Also included are the processes for the preparation of such compound; rodenticidal compositions containing them; and a method for controlling rodents by applying such a composition.
A compound of the formula II ##STR57## in which Z represents a chlorine atom, n is 0, 1 or 2 and R.sup.4 represents ##STR58## in which Hal is a fluorine or chlorine atom and n is 0 or 1, X is a fluorine, chlorine or bromine atom or a CN, CF.sub.3 or OCF.sub.3 group and D represents --OCH.sub.2 -- or --(CH.sub.2).sub.m --, where m is 2 to 3.
A compound according to claim 19 where each n is O, X is a bromine atom and D is O--CH.sub.2 --.
A compound according to claim 19 wherein Hal.sub.n is a chlorine atom.
A compound of the molecular formula II ##STR59## in which Z represents a chlorine atom, n is 0, 1 or 2 and R.sup.4 represents ##STR60## the compound being in cis or trans or mixed cis/trans form.
A compound of the formula ##STR64##
Dependencies are inferred from the claim text.