Cyclic compounds
AssigneeHoffmann-La Roche Inc.
InventorsMichael J. Broadhurst, Cedric H. Hassall, Gareth J. Thomas
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AssigneeHoffmann-La Roche Inc.
InventorsMichael J. Broadhurst, Cedric H. Hassall, Gareth J. Thomas
Estimating the term…
There is presented a process for the manufacture of hexahydronaphthacene derivatives of the general formula ##STR1## wherein one of R.sup.1 and R.sup.2 represents a hydrogen atom and the other represents a hydrogen atom or a hydroxy group of R.sup.1 and R.sup.2 together represent a protected oxo group, R.sup.3 represents a hydrogen atom or a hydroxy or acyloxy group and R.sup.4 represents a lower alkyl or esterified carboxy group or a group of the formula ##STR2## wherein R.sup.5 and R.sup.6 together form an oxo group or a protected oxo group and X represents a hydrogen atom or a hydroxy or acyloxy group or ##STR3## in which n stands for 1 or 2 and Y represents a hydrogen atom or an alkyl or acyl group. Also presented are certain of the novel derivatives per se and various novel intermediates in the process.
The compound of the formula ##STR22## wherein one of R.sup.1 and R.sup.2 represent a hydrogen atom and the other represents a hydroxy group, R.sup.3 represents a hydroxy group and R.sup.43 represents a lower alkyl, carboxy, lower alkoxy carbonyl, benzyloxycarbonyl or a group of the formula:
Dependencies are inferred from the claim text.