Collagen-thrombin compositions
AssigneeSeton Company
InventorGheorghe Cioca
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Abstract
A method of forming a collagen-thrombin hemostatic composition is comprised of forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH and lyophilizing the collagen-thrombin admixture to form a stable collagen sponge having thrombin therein. The collagen utilized in the process is absorbable when placed in vivo. Additionally, a lyophilized collagen product is comprised of collagen which is absorbable when placed in vivo and thrombin distributed within the collagen. The collagen product is storage stable.
Claims10
A method of forming a collagen-thrombin hemostatic composition consisting essentially of:
- forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH, wherein the ratio of collagen to thrombin is about 0.1 gram of collagen to about 300 units or greater of thrombin;
- and
- lyophilizing said collagen-thrombin admixture to form a stable collagen sponge having thrombin distributed uniformly throughout and wherein said collagen is absorbable when placed in vivo.
A lyophilized collagen product, active ingredients consisting essentially of collagen which is absorbable when placed in vivo and thrombin distributed uniformly throughout said collagen, said product being storage stable.
Dependencies are inferred from the claim text.