Cell culture using a monolithic support
AssigneeCorning Glass Works
InventorLee A. Noll
Life of this patent
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Abstract
A novel immobilized cell composite used in a novel apparatus/method for cell culture. The composite comprises: (a) a high surface area monolithic support having a multiplicity of mutually parallel channels passing therethrough, the channels having walls formed of a medium-insoluble, non-toxic, composition and the support having at least about 20 channels per square inch of cross-sectional area; and (b) a population of plant or animal tissue cells anchored to the porous channel walls.
Claims18
An immobilized cell composite comprising:
- (a) a high surface area monolithic support having an inlet and an outlet end, a multiplicity of mutually parallel channels passing therethrough, the channels having walls formed of a medium-insoluble, non-toxic, composition and the support having at least about 20 channels per square inch of cross-sectional area;
- and
- (b) a population of plant or animal tissue cells anchored to the porous channel walls.
A process for culturing plant or animal tissue cells wherein the cells are anchored to a monolithic medium-insoluble, non-toxic support and a cell nutrient medium is flowed past the cells, characterized in that
- (a) the support consists of a monolith having a multiplicity of parallel channels passing therethrough and an inlet and outlet end;
- (b) the channels have walls suitable for cell anchoring;
- and
- (c) the support has at least about 20 channels per square inch of cross-sectional area.
Dependencies are inferred from the claim text.