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US 4,513,006 AGranted
Anticonvulsant sulfamate derivatives
AssigneeMcNeil Lab, Inc.
InventorsBruce E. Maryanoff, Joseph F. Gardocki
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Abstract
Sulfamates of the following formula (I): ##STR1## wherein X is O or CH.sub.2 and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.
Claims12
A sulfamate of the following formula (I):
- ##STR11## wherein X is oxygen;
- R.sub.1 is hydrogen or alkyl;
- and
- R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl and R.sub.2 and R.sub.3 and/or R.sub.4 and R.sub.5 together may be a group of the following formula (II):
- ##STR12## wherein R.sub.6 and R.sub.7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
2 more elements
Dependencies are inferred from the claim text.