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US 4,512,922 AGranted
Purification and activity assurance of precipitated heterologous proteins
AssigneeGenentech, Inc.
InventorsAndrew J. S. Jones, Kenneth C. Olson, Steven J. Shire
Life of this patent
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Abstract
A process for maintaining refractile proteins in solubilized form by replacing the strongly denaturing solution with a weakly denaturing solution.
Claims9
A process for solubilizing and maintaining the solubility of protein precipitated in the form of refractile bodies in a host cell culture, comprising solubilizing said refractile bodies in a strongly denaturing solution, and replacing the strongly denaturing solution with a different weakly denaturing medium while keeping the protein solubilized.
Dependencies are inferred from the claim text.