Phenanthrene derivatives
AssigneeBurroughs Wellcome Co.
InventorKenneth W. Bair
Life of this patent
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Abstract
The present invention relates to compounds of formula (I) ##STR1## wherein Ar is a phenanthrene or substituted phenanthrene ring system; R.sup.1 is a C.sub.1-3 alkylene moiety; R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; R.sup.3 is a hydroxy C.sub.1-6 alkyl group; R.sup.4 and R.sup.5 are the same or different and are hydrogen, C.sub.1-6 alkyl or hydroxy C.sub.1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R.sup.3, R.sup.4, and R.sup.5 ; Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.
Claims5
A method of reducing the number of susceptible tumor cells which comprises contacting said tumor cells with an effective amount of 2-methyl-2-((9-phenanthrylmethyl)amino-1,3-propanediol, or a pharmaceutically acceptable salt thereof, or 2-methyl-2-((2-phenanthyrlmethyl)amino)-1,3-propanediol, or a pharmaceutically acceptable salt thereof.
A compound which is 2-methyl-2-((9-phenanthrylmethyl)amino)-1,3-propanediol or a C.sub.1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
A compound which is 2-methyl-2-((2-phenanthrylmethyl)amino)-1,3-propanediol or a C.sub.1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.