Anti-streptolysin O latex reagent and process for the preparation thereof
AssigneeBehringwerke Aktiengesellschaft
InventorTibor Toth
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Abstract
A process for the preparation of an antistreptolysin O latex reagent and the reagent produced by such process. The reagent is prepared by reacting streptolysin O with a bifunctional low molecular weight compound and, in the preferred embodiment, with a gamma globulin or a Fab fragment thereof to form a product, which product is adsorbed to latex particles. The reagent is stable and may be used for the determination of antibodies to streptolysin O.
Claims20
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting streptolysin O with a bifunctional low molecular weight compound to form a product and adsorbing said product to latex particles.
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting streptolysin O with a bifunctional low molecular weight compound and with a compound selected from the group consisting of a gamma globulin and a Fab fragment of a gamma globulin to form a product and adsorbing said product to latex particles.
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting a Fab fragment of a gamma globulin with a bifunctional low molecular weight compound, separating any excess or unreacted bifunctional low molecular weight compound, adding streptolysin O, and adsorbing the product to latex particles.
Dependencies are inferred from the claim text.