Production of pulverulent mixtures of lipidic and hydrophobic constituents

A method for producing a pulverulent material of at least one amphiphilic lipidic constituent and at least one constituent of at least partially hydrophobic character, said material being used in particular for forming hydrated lipidic lamellar phases such as liposomes or the like,

• said method comprising
• dissolving in a non-aqueous solvent, said amphiphilic lipidic constituent and said at least partially hydrophobic constituent, to form a solution of the same, and
• atomizing the thus-formed solution in a flow of hot gaseous fluid to produce said pulverulent material.

A method for producing a pulverulent material of at least one amphiphilic lipidic constituent, said material being used in particular for forming hydrated lipidic lamellar phases such as liposomes or the like, comprising

• dissolving in a non-aqueous solvent, said amphiphilic lipidic constituent to form a solution of the same, and
• atomizing the thus-formed solution in a flow of hot gaseous fluid to produce said pulverulent material,
• said solvent being selected from the group consisting of chloroform, methanol, ethanol, dichloromethane, a material of chloroform with methanol, and a mixture of chloroform with ethanol.

A method for producing a pulverulent material of at least one amphiphilic lipidic constituent, said material being used in particular for forming hydrated lipidic lamellar phases such as liposomes or the like, comprising

• dissolving in a non-aqueous solvent, said amphiphilic lipidic constituent to form a solution of said constituent,
• adding to said solution of said amphiphilic lipidic constituent, solid microalveolate particles, thereby obtaining a powder through atomization.

A pulverulent material of at least one amphiphilic lipidic constituent which is obtained by dissolving in a non-aqueous solvent, said amphiphilic lipidic constituent to form a solution of said constituent and by atomizing said solution in a flow of hot gaseous fluid produce said pulverulent mixture.

A method for producing hydrated lipidic lamellar phases, such as liposomes, comprising

• dispersing in a suitable aqueous medium, a pulverulent material at least one amphiphilic lipidic constituent obtained by dissolving in a non-aqueous solvent said amphiphilic lipidic constitutent to form a solution of said constituent, and in atomizing said solution in a flow of hot gaseous fluid to produce said pulverulent material.

Hydrated lipidic lamellar phases, obtained by dispersing in a suitable aqueous medium, the pulverulent material of at least one amphiphilic lipidic constituent obtained by dissolving in a non-aqueous solvent said amphiphilic lipidic constituent to form a solution of said constituent and by atomizing said solution in a flow of hot gaseous fluid to produce said pulverulent material.

A pharmaceutical composition containing a therapeutically efficient proportion of an active constituent which is incorporated or encapsulated in hydrated lipidic lamellar phases obtained by dispersing a pulverulent material of at least one amphiphilic lipidic constituent obtained by dissolving in a non-aqueus solvent, said amphiphilic lipidic constituent to form a solution of said constituent and by atomizing said solution in a flow of hot gaseous fluid to produce said pulverulent material;

• said lamellar phases being mixed with at least one pharmaceutically acceptable excipient or vehicle.

A composition for use as a cosmetic product, comprising an efficient quantity of an active substance which is incorporated or encapsulated in hydrated lipidic lamellar phases obtained by dispersing a pulverulent material of at least one amphiphilic lipidic constituent obtained by dissolving in a non-aqueous solvent, said amphiphilic lipidic constituent to form a solution of said constituent and by atomizing said solution in a flow of hot gaseous fluid to produce said pulverulent material, excipient or vehicle.